The Effect of Statins on Erectile Dysfunction: A Meta‐Analysis of Randomized Trials

The Effect of Statins on Erectile Dysfunction: A Meta‐Analysis of Randomized Trials

Atorvastatin decreased mean LDL cholesterol by 43% and resulted in a significant improvement of sildenafil efficacy in the domain score of 7. Therefore men using statins to improve their cholesterol levels may emerge a significant improvement in erectile function. Common causes of the condition include high cholesterol level, high blood pressure, tobacco use, stress and diabetes.

In this study, a total of 50 potent men without hypercholesterolemia undergoing bilateral nerve‐sparing radical retropubic prostatectomy for clinically localized prostate cancer were prospectively randomized into 2 groups. Statins reduce cholesterol and improve blood flow for all arteries. Gout overview, in addition, the product is all-natural, and oral toxicity studies have shown that it is safe when used as directed. At baseline, the 2 groups had no significant differences, including IIEF‐5 scores, but after treatment, group 2 had a significantly higher postoperative IIEF‐5 score than group 1 at 6 months postoperatively.

That’s not to say there aren’t more serious potential complications with statin use.

It is plausible that lowering cholesterol improves the function of the cells that line blood vessels, which could help erectile function, he said. About 90% of men recovered potency on statin withdrawal, and in some cases impotence appeared again on re-challenge. This ensured that any improvement was directly related to the improvement of endothelial function by drug therapy and not by androgen therapy. In addition, some patients taking atorvastatin achieved a response of 5 to some questions, but none of the participants regained normal erectile function (IIEF-5 score <22). Before starting statins, the median IIEF score was 21 out of a maximum of 25, and 43% of men had scores above 21, indicating no erectile dysfunction. Using larger numbers of patients, this study reevaluated the hypothesis that men with ED resistant to sildenafil can be rescued with the addition of atorvastatin18 or vitamin E. On 05/07/2020 the overall trial end date was changed from 30/11/2020 to 30/09/2020.

In 2020, a study was done by the West China Hospital in Sichuan University that concluded that use of statins reduced testosterone levels. 39 Earlier studies confirmed the antioxidant activities of both vitamin E and atorvastatin. Get tested and see a doctor. In addition, in spontaneously hypertensive rats,35 statins interfered with the RhoA/ROCK-mediated 'excitation–transcription coupling'. “Participants experienced a 43% improvement in their erections, the effect is around half that of sildenafil [Viagra].

The pills are unlikely to be prescribed for the condition in those without cardiovascular risk factors, at least in the near future, the researchers said. However, one recent research indicated that statins was not associated with the increase of morbidity of gonadal or sexual dysfunction in men []. (001)] in patients treated with statins vs controls. Regarding atorvastatin, it was found that atorvastatin interfered with the oxidation process, leading to the reduction of circulating markers of oxidation. The good news is that everything you have to do for continued heart health now also applies to not having ED. A tablet that can take on cholesterol and improve erections may sound attractive. They help lower low-density lipoprotein (LDL or “bad”) cholesterol and raise high-density lipoprotein (HDL or “good”) cholesterol, which can help prevent heart attack and stroke.

About one of six adults in the U.

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The IIEF‐5 score was significantly higher after sildenafil treatment than in the atorvastatin treatment group, and the IIEF‐5 score after combined treatment was significantly higher than in the sildenafil or atorvastatin treatment groups ( Gokkaya et al, 2020 ). There is growing evidence to suggest statins may also cut the risk of cancer and dementia. Conversely, the pleiotropic effects of statin therapy may improve overall vascular health. And when researchers went back to that original 2020 study, they found that over time, statins might actually have helped men achieve erection as opposed to hindering it.

Similarly, it is not known if such an intervention will improve symptoms in patients with established ED.

Introduction

It is estimated that 18 million men in the United States experience erectile dysfunction. However the relative risk for simvastatin (Zocor) was 1. Millions of Americans are prescribed statins to prevent heart disease, but some stop taking the medication or take less than the prescribed dose, Kostis said.

These groups were homogeneous for age, body mass index, and systolic and diastolic blood pressure, and the group of patients treated with hypolipidemic drugs showed a lower level of triglyceride and higher levels of HDL cholesterol compared with the group not receiving hypolipidemic medication. Compared with placebo, quinapril improved symptoms of ED significantly, as measured by the International Index of Erectile Function 5 (IIEF‐5) questionnaire. There are some limitations to this study, some of which are described by the authors:

They are effective, which is why cardiologists prescribe them for their patients at risk for heart attack, coronary heart disease, angina and stroke.

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On the plus side, some men report improved erections when their high cholesterol was treated with statins, said Dr. Overall, erectile function scores increased by 3. Atorvastatin was associated with a statistically significant improvement in the mean IIEF-5 score (P =. )

Men who took statins (+/- sildenafil) generally saw their IIEF scores improve, indicating better erectile function. To yellow card reporting in different countries can be added the prospective cohort study. The research included 100 men between the ages of 40 and 70 with erectile dysfunction and abnormal cholesterol. The researchers’ analysis found that statins did improve scores on the International Inventory of Erectile Dysfunction – a well-validated “scorecard” for erectile dysfunction. Neither blood pressure lowering with candesartan/HCTZ nor cholesterol lowering with a statin showed an impact on erectile function. The most recent literature has demonstrated in rat models of ED that atorvastatin (most frequently analyzed in the studies on ED) restores erection by down‐regulation of penile RhoA/Rho‐kinase (ROCK) signaling through the reduction of geranyl pyrophosphate, an essential step in RhoA activation ( Fibbi et al, 2020 ; Morelli et al, 2020 ). In other words, statins may be pretty powerful in improving sexual function, especially since the chief purpose of these drugs is to treat high cholesterol.

In the subgroup of patients receiving statins the IIEF score emerged a statistically significant increase after three months of treatment (16. )However, he added that statins can also be a "double-edged sword", since previous research has shown they can decrease testosterone, which cuts back on sexual drive and energy. Kostis hopes that the immediate benefit of improving erectile function might improve adherence to statin therapy, helping to prevent more heart attacks in men with high cholesterol. The subjective score in the atorvastatin group increased from a baseline average of 11. Beta blockers can raise blood sugar (Drug Intelligence & Clinical Pharmacy, April 1985). Men being treated for cardiovascular risk factors such as high blood pressure and high cholesterol are at increased risk of developing ED and often consider this condition a side effect of their medications. The other three compared statins plus sildenafil with placebo plus sildenafil.

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The lower levels of total and calculated free testosterone observed in patients treated with statins were also confirmed, comparing them with agewaist circumference and cardiovascular risk score matched controls. Cholesterol lowering drugs ‘reduce erectile dysfunction’,” reports the Daily Mail. Some information on the possible mechanisms of these side effects have been obtained, but the intimate mechanism remains uncertain. After starting statins, the median IIEF score fell to 6. “Make sure you have a doctor who listens to you. Earlier clinical studies reported that atorvastatin showed a 7. Heart attack symptoms: the sign condition shares with coronavirus – what to look out for. Another important aspect concerns the modulation of endothelial function carried out with the use of statins.

I recently had my cholesterol checked again, and it has dropped all the way to 111.

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(3 percent increase). Do lipid-lowering drugs cause erectile dysfunction? I want to know if there is anything I can take for arthritis pain that will not give me stomach ulcers, raise my blood pressure or lead to a heart attack. 7 million, according to the federal Agency for Healthcare Research and Quality. Recent research suggests that statins may be able to treat ED more generally. Can low testosterone (low t) cause erectile dysfunction?, air is evacuated from the cylinder by means of the pump, creating a vacuum, which produces the erection. Additionally, a trend toward improvement in IIEF‐5 with atorvastatin was significant.

We have heard from many other men who, like you, believe that statins contributed to their sexual problems. None of the patients taking atorvastatin achieved a response of 5 to the IIEF‐5 questions, and none of the patients regained normal erectile function as defined by an IIEF‐5 score greater than 21 ( Dadkhah et al, 2020 ). And in small to medium doses, none of these are at issue. The same cardiology congress that brought us statins for erectile dysfunction had Professor Giovanni de Gaetano’s study showing that a diet of fish, vegetables, nuts and oils can reduce early death from heart disease by 37%. My cholesterol was elevated to 290, so my doctor prescribed atorvastatin. During the study, none of the treatment groups were associated with a significant change in erectile function when compared to their respective placebo groups. Subgroup analyses revealed trends in the atorvastatin group to indicate that a change in the IIEF‐5 score is affected by age, severity of ED, and baseline serum levels of LDL. Many older men have erectile dysfunction along with diabetes and atherosclerotic disease, for which they are frequently prescribed statins, Kostis noted.

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A systematic review is an overview of primary studies. Additionally, maximum NO‐dependent nonadrenergic, noncholinergic nerve‐mediated relaxation of corpus cavernosum reduced by 25%–33% by diabetes was prevented by 75% and reversed by 71% after rosuvastatin treatment. Yet randomised trial results show no increase in erectile dysfunction rates with statins, and these were large trials, like 4S, conducted over a long period of time. Clinical evidence has shown a synergism with sildenafil in poor responders. Simvastatin one 40 mg tablet orally daily at bedtime for 6 months or matched placebo one tablet orally daily at bedtime. Overall, the researchers determined that statins (+/- sildenafil) might improve ED when compared with placebo (+/- sildenafil). Learn more about the differences between HDL and LDL cholesterol here. Over half of men had a fall in 5 or more points on IIEF with statins, and 22% experienced new onset erectile dysfunction.

In 57% of cases, recovery occurred after withdrawal of statin, implying, somewhat ominously, that recovery did not occur in 43% of cases by the time of reporting. How did the researchers interpret the results? (80; Bruckert et al, 1996). 9 points in men who took statins - from 11. Erectile function was evaluated before and after all treatment regimens according to the IIEF‐5 questionnaire. 4 points in men who took statins, which is equal to a 25% increase in overall sexual function.

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The study is published in the Canadian Journal of Cardiology. Stop smoking (if you’re a smoker). (4%) cases of ED were found among the remaining 106 214 reports not exposed to statins. This study was of short duration (six weeks), so long-term outcomes of atorvastatin (Lipitor) to treat erectile dysfunction in men that have failed to improve on sildenafil (Viagra) are not known. In addition, atorvastatin is a promising drug that can be used as salvage treatment for sildenafil failure.

Although two studies showed no significant improvement in erectile function they both showed a larger improvement in men with more severe ED and one study showed a significant improvement in male EDquality of life. Atorvastatin inhibited RhoA membrane translocation and ROCK activity and restored penile erection. Erectile dysfunction (ED) is a major public health problem.

Although not statistically different, the frequency of men able to achieve intercourse by vaginal penetration without PDE5i was 40% in group 2 compared with 17.

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Statins are often prescribed to reduce LDL cholesterol levels. Currently, the number of molecules available have a similar chemical structure, although differing in pharmacokinetics and drug interactions ( Sweetman, 2020 ; Table ). Actions, iSBN 9780876300831 . Finally, there was no statistically significant difference in penile erection after intake of simvastatin or placebo (Mastalir et al, 2020). The study group was divided in two subgroups each consisting of 50 patients.

The good news is that the problem is reversible on stopping statins, and that drug switching helped in a number of cases. Taken together, these results indicated that increasing NOS activity was expected to be the major mechanism for NO increase and for improvement of both endothelial dysfunction and ED. We are only now beginning to realize the wide-ranging importance of cholesterol in human physiology. Although the methods used by the researchers were sound, the 11 randomised controlled trials included in the analysis only included a total 713 men. As indicated from results, atorvastatin had antioxidants activities (the increase in GPO), anti-inflammatory activities (the decrease in CRP and IL-6) and enhancement effects on NOS activity, in addition to increasing NO production and improving erectile function tests. Of course, statins are not recommended solely for the treatment of erectile dysfunction in patients with healthy cholesterol levels. She thinks I am losing interest in her or that there is someone else. The three observational before and after studies did not show a significant difference in IIEF score before and after statin administration.

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Finally, total plasma cholesterol was unaltered by diabetes or treatment with rosuvastatin ( Nangle et al, 2020 ). It seemed to do very little for the heart condition but trial volunteers reported they were getting a lot of erections. In another study, Fibbi and colleagues ( 2020 ) evaluated the effects of atorvastatin (5 and 30 mg/kg), given for 2 weeks to spontaneously hypertensive rats (SHR), on an experimental model characterized by impaired erectile function and overactivity of the procontractile RhoA/Rho‐associated, coiled coil‐containing protein kinase (RhoA/ROCK) pathway compared with their normotensive counterpart, Wistar‐Kyoto rats.

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Diclofenac can be irritating to the digestive tract. Since statins are the most commonly prescribed drug in the UK, will erectile dysfunction (whatever doctors call the condition, it still sounds pejorative) be consigned to history? Other experimental data concerning rosuvastatin, in particular, was investigated by Nangle and colleagues ( 2020 ), who examined the effects of treatment with rosuvastatin on corpus cavernosum and aorta from streptozotocin‐induced diabetic mice in a 4‐week prevention study and a 2‐week intervention study after 4 weeks of untreated diabetes. Thus, the CRP test might be less sensitive. Is high cholesterol good for some? Methods A literature review was performed to identify all published randomized double‐blind, placebo‐controlled trials of statins for the treatment of ED. You can read about them here.

Corresponding Author

In the Scandinavian simvastatin survival study, 4444 patients with coronary heart disease were randomized to treatment with simvastatin or placebo for up to 6. There are two main types of cholesterol: That statins may also be the cause of erectile dysfunction is another matter, but the evidence does seem to be growing. Improvement in ED score with sildenafil was reassessed at 6 and 12 weeks of treatment with atorvastatin (80 mg daily) or placebo. Many of us may try other drugs in the same class, which is commonly an exercise in futility.